A drug cocktail combining low doses of three medications was able to increase the life span of fruit flies by 48%. With increasing life expectancy in humans, therapeutic mixtures like this could potentially prevent diseases associated with aging and give people healthy final years.
This is demonstrative of what we should be able to do in the future to modify aging in humans. Unfortunately, the drugs they are using are not drugs that you should take due to the adverse side effects. Lithium in low doses is relatively safe. However, Trametinib is it cancer drug so it is very aggressive, and has numerous side effect: https://www.mayoclinic.org/drugs-supplements/trametinib-oral-route/side-effects/drg-20061171. Rapamycin unfortunately compromises your immune system, and has adverse reactions occurring at a frequency of ≥20% in the Rapamune treatment group and greater than placebo including stomatitis, diarrhea, abdominal pain, nausea, nasopharyngitis, acne, chest pain, peripheral edema, upper respiratory tract infection, headache, dizziness, myalgia, and hypercholesterolemia.
The good news is we know the pathways that it works on, and scientists will sort it out to find analogs that are safer.